Myoglobin & Hemoglobin

Myoglobin

Secondary Structure

Composition

Take cross-sections

Hemoglobin

Subunits

Secondary Structure

Subunit structures:
Alpha
Beta

Oxygen Binding

The Heme Prosthetic Group

The Heme Binding Site

The Proximal Histidine

Oxygen-binding and the Distal Histidine

Allostery and Hemoglobin

Allosteric change
Deoxy-hemoglobin
Oxy-hemoglobin

2,3-BPG

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Identify the proximal and distal histidines
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Chemical nature of the hemoglobin sidechains that hold 2,3-BPG in place
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For specific instructions on how to manipulate the 3D images in this tutorial, see Structure Tutorial Help.

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